NMN Longevity gene activator

Description:

This supplement combines cutting-edge anti-aging ingredients known for their ability to support cellular vitality, energy metabolism, and skin health. Through NMN’s boost to NAD+ levels, it helps activate cellular repair and longevity processes, while trans-resveratrol provides antioxidant protection that supports heart health and cognitive resilience. Polyamine-rich yeast extract aids in cellular regeneration and gut health, while Peucedanum japonicum and Sakura Extract deliver powerful antioxidant and skin-protecting benefits. This synergy targets overall vitality, aiding in metabolic health, anti-inflammatory effects, and a youthful complexion.

 

NMN: 

NMN (β-Nicotinamide Mononucleotide) is a compound that plays a significant role in anti-aging research and cellular health. Here’s a structured description that incorporates key details from your provided files:

 

NMN (β-Nicotinamide Mononucleotide):
NMN, a derivative of vitamin B3, is found naturally in cells and acts as a precursor to NAD+ (nicotinamide adenine dinucleotide), an essential molecule that fuels cellular energy production and activates longevity-related genes. Research on NMN emphasizes its potential to slow down aging processes, boost energy, and maintain cellular health by supporting essential functions.

 

Anti-Aging Support:

• Activation of Sirtuin Genes: NMN boosts NAD+ levels, which in turn activate sirtuin genes, commonly referred to as “longevity genes.” Sirtuins help protect cells by enhancing mitochondrial function, promoting DNA repair, and guarding against oxidative stress.
• Telomere Protection: Telomeres, the protective ends of chromosomes, shorten with each cell division, contributing to cellular aging. NMN supports telomere maintenance, aiding in cellular longevity and reducing signs of aging on a molecular level.
• Energy Metabolism and Mitochondrial Health: By elevating NAD+ levels, NMN revitalizes mitochondrial function, enhancing the body’s energy production and supporting muscle health, particularly valuable as the body ages.

 

Research Highlights:

• Longevity and Organ Health: Studies in animal models have shown that NMN intake can enhance cognitive and physical functions, reflecting a more youthful biological state.
• Reduced Inflammation and Improved Metabolic Health: NMN has demonstrated potential benefits in managing inflammation and maintaining healthy blood sugar levels, contributing to overall metabolic balance.

 

Scientific Insights on Longevity and Cellular Health:

• Telomeres and Human Healthspan: Telomeres, DNA sequences that cap chromosome ends, gradually shorten with cell division and oxidative stress, and are linked to age-related diseases. Studies show that shortened telomeres correlate with increased health risks, serving as markers rather than direct causes of these risks. Research has shown that maintaining high levels of telomerase, the enzyme that extends telomeres, can delay telomere shortening and rejuvenate immune cells. This finding opens potential avenues for telomerase-based therapies aimed at enhancing healthspan in the elderly (Effros, J Gerontol a Biol Sci Med Sci, 2009).
• Telomeric Complexes and Longevity: Advances in anti-aging and cancer research suggest that targeting telomeres and their associated proteins can play a role in extending lifespan without increasing cancer risk. Specific telomeric binding proteins help stabilize telomere structure and prevent DNA damage, underscoring the potential for these factors to serve as biomarkers or therapeutic targets for aging and cancer (Protein & Cell, 2013).
• Sirtuins and Mitochondrial Function: Mitochondrial sirtuins (SIRT3, SIRT4, SIRT5) are essential for cellular energy metabolism and redox balance. They modulate gene expression and enzyme activity, enhancing mitochondrial function and defending against oxidative stress, insulin resistance, and type 2 diabetes. These findings emphasize the importance of sirtuins in protecting against aging-related metabolic disorders (Wang & Wei, Int. J. Mol. Sci., 2020; Li & Cai, J. Biomed. Res., 2023).

 

Trans-Resveratrol: 

Trans-Resveratrol is a polyphenolic compound recognized for its potent antioxidant properties, commonly found in red wine, grape skins, seeds, and peanuts. This powerful antioxidant has gained significant attention as a potential contributor to the “French Paradox”—a phenomenon describing the low incidence of heart disease among French populations despite diets high in animal fats. Research suggests that the polyphenols in red wine, particularly resveratrol, may be one of the factors behind this paradox, supporting cardiovascular health through a range of mechanisms.

 

Health Benefits of Trans-Resveratrol:

• Cardiovascular Protection: Trans-resveratrol has been shown to protect cardiovascular health by reducing inflammation and improving endothelial function. It increases endothelial nitric oxide synthase (eNOS) activity, enhancing blood flow and reducing oxidative stress, which helps prevent heart disease (Gojkovic-Bukarica et al., Vojnosanit. Pregl., 2013).
• Neuroprotective Effects and Potential in Neurodegenerative Disease Prevention: Research indicates that resveratrol may offer neuroprotection, potentially delaying or reducing the progression of neurodegenerative diseases like Alzheimer’s and Parkinson’s. By activating SIRT1, resveratrol modulates important cellular pathways (e.g., PGC-1α, FOXO family, Akt) involved in neuroprotection and anti-aging effects (Pallas et al., Current Neurovascular Research, 2009). This suggests its possible use in maintaining cognitive function with aging.
• Eye Health and Protection Against Oxidative Stress: Studies on human retinal pigment epithelial (RPE) cells have demonstrated that trans-resveratrol can protect these cells from oxidative stress, a major factor in age-related macular degeneration. In cultured cells, resveratrol significantly enhanced antioxidant enzyme activities, such as superoxide dismutase and catalase, which protect against hydrogen peroxide-induced damage (Journal of Ocular Pharmacology and Therapeutics, 2011).
• Enzyme Inhibition for Anti-Inflammatory Effects: Trans-resveratrol effectively inhibits various oxidative enzymes, including superoxide dismutase and lipoxygenase, thereby reducing oxidative damage in cells. This inhibition suggests anti-inflammatory potential, which may contribute to reducing oxidative stress-related cellular damage (Food Science & Technology, 2006).

 

Yeast Extract with Polyamines and Nucleic Acids: 

This yeast extract is rich in nucleotides (such as cytidine, adenine, and uridine) and polyamines (like spermine, spermidine, and putrescine). This combination plays a crucial role in cellular health and helps counteract age-related decline. Both nucleotides and polyamines are essential for numerous cellular processes, supporting regeneration and metabolic health. Polyamines, in particular, stabilize cellular structures, while nucleotides are integral for DNA/RNA synthesis and cellular repair.

Composition and Concentration:

• Nucleotides: Over 35% concentration, supplying fundamental building blocks for DNA and RNA synthesis, which are vital for cell repair and renewal.
• Polyamines: More than 0.2% concentration, including key compounds like spermine, spermidine, and putrescine, essential for cellular integrity, promoting growth, and structural stability within cells.

 

Physiological Role of Polyamines:

Polyamines such as spermidine and spermine support cell division, enhance gut health, and show potential in extending lifespan by mitigating cellular aging processes. Polyamines are abundantly found not only in soybeans but also in fermented soy products like natto, soy sauce, and miso. Japanese people, who traditionally consume fermented soy products, often exhibit longevity, which is attributed in part to the high polyamine levels in their diet.

 

Nucleotides in Metabolic Health:

Nucleotides play a key role in promoting metabolic health by supporting liver regeneration and immune response. They also contribute to gastrointestinal health by stimulating the growth of beneficial gut bacteria.

 

Research Insights:

• Cognitive Health: The importance of polyamines like spermidine and spermine in cognitive function has been increasingly noted, especially as levels of these compounds decline with age. Research published in Neurochemical Journal (2022) suggests that supplementing with polyamines can prevent cognitive impairment and slow disease progression. Studies in several European countries are examining the impact of polyamine-rich diets on cognitive processes and neurotransmitter regulation in aging populations.
• Yeast and Aging: Research on the yeast Saccharomyces cerevisiae has highlighted that specific metabolites, including spermidine, act as second messengers in chronological aging, regulating cellular processes essential for longevity. This finding, published in Int. J. Mol. Sci. (2018), underscores the potential of polyamines as longevity-promoting agents by influencing metabolic and stress response pathways.

 

Key Functional Benefits:

• Cellular Longevity and Regeneration: Nucleotides and polyamines in yeast extract aid DNA repair and replication, essential for cell regeneration. By stabilizing and protecting DNA, they help mitigate signs of aging at the cellular level.
• Enhanced Metabolism and Energy Production: Polyamines activate metabolic pathways that promote cellular energy production, supporting improved vitality and a youthful cellular environment.
• Support for Immunity and Anti-Inflammatory Actions: By reducing cellular damage, yeast extract with polyamines can bolster immune function and reduce inflammation, valuable for countering age-related immune decline.
• Neuroprotective Properties: Polyamines may also protect neurons from oxidative damage, aiding nerve cell regeneration, which could benefit cognitive health and resilience against neurodegenerative processes.

This yeast extract with polyamines and nucleic acids offers a potent blend of benefits, supporting everything from cellular integrity and anti-aging to cardiovascular and cognitive health. This multifaceted ingredient is a powerful addition to health products targeting longevity and cellular vitality.

 

Peucedanum japonicum (Botanboufu):

Peucedanum japonicum, commonly known as Botanboufu or Chomeisou, is a perennial herb growing along the rugged coastlines of Okinawa. Known for its resilience in harsh environments, this plant has earned its reputation as the “longevity herb” due to its high nutritional and antioxidant profile.

Nutritional Composition:

Botanboufu is packed with beneficial compounds, including:

Polyphenols: (1380 mg per 100g) such as chlorogenic and neochlorogenic acids, which are powerful antioxidants.

Rutin: (45 mg per 100g), a component that strengthens blood vessels and supports healthy circulation.

Vitamins: Rich in Vitamin A, β-carotene, Vitamin C, and Vitamin E.

Minerals: High in calcium, potassium, and magnesium, supporting bone and cardiovascular health.

Dietary Fiber: Contains 46.8g of fiber per 100g, beneficial for digestive health.

Health Benefits:

• Antioxidant Activity: Chlorogenic acids in Botanboufu are effective at neutralizing free radicals, providing protective effects against cellular damage and aging.
• Improved Circulation: Rutin in the herb helps improve blood flow, which may prevent issues associated with poor circulation, like high blood pressure and atherosclerosis.
• Supports Heart Health: The antioxidant properties of polyphenols, along with rutin’s ability to strengthen capillaries, contribute to cardiovascular health.
• Anti-inflammatory: Botanboufu may alleviate conditions like asthma, rheumatism, and pleurisy, traditionally used in Okinawa for respiratory and inflammatory issues.

Traditional Use:

In Okinawan culture, young or dried leaves of Botanboufu are commonly added to dishes with meat or used in broths for their health-boosting properties. This herb’s historical use as part of a traditional diet aligns with its health-supportive effects observed today.

Peucedanum japonicum’s potent composition of polyphenols, fiber, and essential vitamins makes it a valuable ingredient for promoting longevity and overall vitality.

 

Sakura Extract (Cherry Blossom):

As skin ages, it undergoes a natural glycation process where sugars bind to proteins like collagen and elastin, forming advanced glycation end-products (AGEs). This glycation process results in stiffening and loss of elasticity, leading to visible signs of aging, including wrinkles and dullness. Additionally, oxidative stress and melanin production contribute to pigmentation issues, further diminishing skin’s youthful appearance.

Derived from cherry blossoms (Prunus lannesiana), Sakura Extract is rich in potent bioactive compounds such as Caffeoyl Glucoseand Quercetin Glucoside, known for their anti-glycation and antioxidant properties. These components help combat aging on multiple fronts by protecting skin structures and promoting a healthier complexion.

Key Benefits and Mechanisms:

• Anti-Glycation and Collagen Protection: Sakura Extract significantly inhibits the formation of AGEs, reducing collagen cross-linking and maintaining skin elasticity. Studies reveal that caffeoyl glucose, a primary component, actively prevents glycation even at low concentrations, protecting skin from the structural damage caused by AGE accumulation. It also helps prevent apoptosis (cell death) of fibroblasts, the cells responsible for collagen synthesis, further supporting skin integrity and resilience.
• Enhanced Collagen Formation: This extract promotes collagen lattice formation within fibroblasts, which supports skin’s extracellular matrix, leading to firmer, more youthful-looking skin.
• Anti-Melanin and Skin Brightening: Sakura Extract has shown efficacy in inhibiting melanin production in skin cells. By decreasing tyrosinase activity, an enzyme crucial to melanin synthesis, it can help reduce pigmentation and improve skin tone for a brighter complexion.
• Antioxidant Defense: Rich in flavonoids, Sakura Extract protects against oxidative damage caused by environmental stressors, helping to reduce skin dullness and maintain a vibrant, healthy appearance.