HIMEMATSUTAKE Immune Booster

Description: 

The Himematsutake supplement is specifically focused on bolstering the immune system and utilizing the energy-providing properties of polysaccharides. It aims to enhance overall well-being by addressing concerns such as chronic fatigue, blood sugar balance, mood elevation, blood pressure regulation and fortified immunity. It is indicated for individuals with weakened immune systems, as well as for those seeking prevention and treatment of various conditions, including benign and malignant tumors, cardiovascular health, infectious diseases, and diabetes prevention.

 

Himematsutake Mushroom:

This mushroom is also known as Agaricus blazei Murrill, is increasingly drawing the attention of researchers and health professionals due to its extraordinary health-promoting properties, including its role in cancer prevention and enhancing the immune system.
Initially found in Brazil and now widely cultivated in Japan, Himematsutake mushroom is recognized for its potential anti-cancer capabilities. Key researchers like Dr. Iwa, who accomplished the first artificial cultivation of this mushroom back in 1975, have paved the way for significant advancements in its cultivation and study.

The Iwade Institute of Mycological Research, with facilities in Japan and Paraguay, Brazil, directly engages in the cultivation of Himematsutake, managing specialized farms while upholding stringent quality control measures. The mushroom’s mycelium (strain ITO-S) is also processed in certified facilities to maintain the highest manufacturing standards.
In terms of classification, the globally-renowned Agaricus systematist, Dr. Heinemann, has categorized the mushroom as Agaricus blazei Murrill. This name, “Himematsutake,” was accepted and disseminated by the Japanese Society of Mycological Sciences, and it was officially included in Japanese publications by 1987. It is crucial to differentiate between Himematsutake and the broader term “Agaricus mushroom,” as the Agaricus genus contains over 100 species, including Himematsutake.
Research into the anti-tumor effects of mushrooms initiated in 1965, with substantial contributions towards the study of Himematsutake. The mushroom’s anti-cancer properties don’t directly act on tumor cells but rather stimulate the immune system, activating macrophages, T-helper cells, NK cells, and other immune cells.

Scientists have identified various active anti-tumor ingredients in Himematsutake, including β-glucan, heteroglycan, peptide glucan, proteoglycan, among others. A small RNA with notable anti-tumor activity has also been isolated from the fruiting bodies of Himematsutake.
Pioneering researchers like Dr. Hitoshi Ito, an associate professor at the Medical Faculty of Mie University and a leading researcher in the study of Himematsutake in Japan, have helped identify Himematsutake strains with high anti-cancer activity, such as Iwade strain 101, registered as ITO-S.

The Himematsutake mushroom, now an FDA-approved health supplement, utilizes a patented “Cell Wall Disruption Method” to maximize its nutritional potential. Both its fruiting body and mycelium, utilized differently in the Iwade 101 and ITO-S strains, are rich in nutrients. Thanks to a patented process, the water-insoluble β-(1-6)-D glucan and nucleic acids within it are accessible. The supplement combines fruiting body powder and mycelium extract, offering full benefits of the multi-patented Himematsutake.

 

Bioactive Components and Immune Activation:

The Himematsutake mushroom (Agaricus blazei) contains a variety of bioactive components, contributing to its potential value in combating cancer. Notably, it is rich in polysaccharides, including β-D-glucan, heteroglycan, peptide-glucan, proteoglycan, as well as chitin, lectin, terpenoids, steroids, nucleic acid complexes (RNA), and dietary fibers.
These polysaccharides, particularly β-D-glucan, stimulate immune-competent cells such as macrophages, T-helper cells, and NK cells. Unlike traditional chemotherapy agents that have a direct cytotoxic action, these polysaccharides act as a biological response modifier (BRM), enhancing the body’s immune function.

 

Anti-Tumor Activity through RNA Molecules:

An intriguing discovery in Himematsutake is a distinct small RNA molecule, weighing approximately 10,000 in molecular weight, which exhibits significant anti-tumor activity. This RNA molecule contains modified bases in addition to the typical adenine, cytosine, and uracil bases. It also includes a small amount of glucose along with ribose as the constituent sugar, protein, and phosphoric acid. This fungal-origin nucleic acid demonstrates BRM-like anti-tumor activity, thus garnering attention.

 

ATOM Complex and Host-Mediated Anti-Tumor Mechanisms:

Research published in “Anticancer Research” discussed the ATOM complex, a polysaccharide-protein complex derived from Himematsutake. The complex demonstrated substantial anti-tumor activity against four established types of mouse tumors. The authors suggested that the mechanism underlying this effect is not direct cytotoxic action on the tumor cells but host-mediated immunological mechanisms, including macrophage activation and alterations of the third component of complement. This further supports the concept of Himematsutake as an immunotherapeutic agent.

 

Expanded Anti-Cancer Action: The Role of Fatty Acids and Steroids:

Research also suggests that components of Himematsutake other than polysaccharides, notably lipids like linoleic acid and other specific fatty acids (stearic acid, oleic acid, and palmitoleic acid), influence survival rates in mice with Ehrlich’s ascites carcinoma. In one study, administration of the fat fraction at a dose of 300 mg/kg increased survival duration significantly compared to the control group. Furthermore, six types of steroids have been extracted from Himematsutake, with three exhibiting inhibitory activity on the growth of cervical cancer cells. These findings underscore the importance of Himematsutake’s diverse components, including polysaccharides, fatty acids, and steroids, in its anti-cancer action.

 

Clinical Studies and the Preventive Role in Diabetes:

In a study published in “Medicine and Biology,” the efficacy of the Agaricus blazei Murrill product (Iwade Strain 101) was examined in patients with various types of cancer. The intake of the Agaricus product for either 30 or 90 days led to an improvement in the overall health status or quality of life in most patients, suggesting a correlation between the duration of intake and health improvement.
Apart from cancer, animal studies indicate that the Himematsutake mushroom can significantly reduce the risk of diabetes. Mice on a Himematsutake-inclusive diet experienced a noticeable decrease in blood glucose levels. After 4 weeks, glucose concentration dropped by 30%, and the blood sugar-lowering effect persisted even after 6 weeks. This points to a potential role of Himematsutake in preventing the onset of type 2 diabetes.

 

 

Ginkgo Biloba: 

The Ginkgo biloba tree, one of the most ancient tree species, has been revered for its medicinal benefits for centuries. Its leaves, specifically, have garnered significant attention in both traditional medicine and contemporary pharmacology.

 

Key Components:

The specialized extract from these leaves, known as GBE, contains:

Terpenoids (6%): Includes ginkgolides A, B, C, J, and bilobalide.

Flavonoid Glycosides (24%): Such as quercetin, kaempferol, and isorhamnetin.

Organic Acids (5-10%): Contributing to the water solubility of the extract.

Of these, the flavonoids and terpenoids are recognized for their primary pharmacological activity.

 

Potential Health Benefits:

Neuroprotection: GBE’s rich composition has demonstrated neuroprotective qualities. It offers potential benefits for age-related neurodegenerative dementias and conditions like Alzheimer’s and Parkinson’s diseases.

Vascular Support: The extract has shown promise in addressing peripheral vascular issues, aiding cerebral blood flow, and potentially reducing fatigue and improving attention.

Antioxidant & Anti-Inflammatory: The flavonoids and terpenoids in Ginkgo biloba offer robust antioxidant and anti-inflammatory effects. This positions Ginkgo as a potential combatant against oxidative stress, commonly linked to age-related diseases.

Combatting Amyloidogenic Effects: Research suggests that Ginkgo biloba might inhibit the buildup of amyloid plaques, one of the hallmarks of Alzheimer’s disease.

Mental Health: Preliminary studies suggest that Ginkgo biloba might have a positive influence on conditions like depression and anxiety, offering a holistic approach to cognitive well-being.

 

Folic Acid (Vitamin B9):

 

DNA Synthesis and Repair:

Vital for creating and repairing DNA, especially in rapidly dividing cells.

Cell Division and Growth:

Highly demanded in tissues with rapid turnover like the skin, digestive tract, and bone marrow.

Red Blood Cell Formation:

Necessary in the bone marrow for nucleotide synthesis for DNA replication. Its deficiency can cause megaloblastic anemia, where large, immature blood cells are produced.

Pregnancy:

Crucial for fetal growth and development; a lack can result in neural tube defects in babies.

 

Riboflavin (Vitamin B2):

 

Energy Production:

Riboflavin aids in converting carbohydrates to glucose, fueling the body. It’s vital for metabolizing fats and protein.

Antioxidant Role:

Riboflavin combats free radicals, which can damage cells and contribute to aging and diseases. By acting as an antioxidant, riboflavin reduces potential damage.

Vitamin Interactions:

Helps the body utilize vitamin B6 and folate.

Growth and Red Blood Cell Production:

Essential for normal growth and the generation of red blood cells, which distribute oxygen throughout the body.

Eye Health:

Riboflavin supports vision and may potentially help in preventing cataracts, though more research is needed to validate its sole effect.

Immunity and Detox:

Riboflavin aids in forming antibodies and detoxifying the lungs, defending against harmful agents.

Growth and Reproductive Health:

Supports overall growth, reproductive organ function, and other crucial areas like the thyroid gland.

 

Deficiency symptoms include fatigue, slowed growth, digestive issues, mouth sores, tongue swelling, eye fatigue, throat soreness, light sensitivity, and cataracts.

 

Vitamin C (Ascorbic Acid):

 

Immune Booster: 

 Vitamin C fortifies the immune system, offering protection against viruses and bacteria.

Wound Healing:

Accelerates the body’s natural wound healing processes.

Hormone Synthesis:

Plays a role in the production of specific hormones.

Blood Formation and Capillaries:

Regulates hematopoiesis (blood cell formation) and ensures the right capillary permeability.

Collagen Production:

Essential in synthesizing collagen, a protein that maintains the structure of our skin, cartilage, and bones.

Antioxidant:

Protects cells from the harmful effects of free radicals, potentially reducing the risk of chronic diseases like heart disease and cancer.

Iron Absorption:

Enhances the body’s ability to absorb and store iron, a crucial element for blood production.

Deficiency Risks:

Individuals who smoke, have particular gastrointestinal issues or cancers, or don’t consume enough fruits and vegetables might be at risk.