Does not contain GMO, gluten, sugar, lactose, pork protein
Package: 120 tablets in a glass jar
Certificates:
Direction for use:
Adults take 4 tablets in the evening, after meals, with water.
168,00 €
Description:
The White Curcuminoid Glutathione supplement presents a holistic approach towards improved skin health and overall wellness. Its active formula, primarily featuring a unique non-white variant of curcumin called tetrahydrocurcuminoid, is designed to resolve a spectrum of skin issues and promote healthier metabolic functions. The supplement’s efficacy lies in its ability to improve problematic skin, alleviate adult acne, balance pigmentation, combat dermatitis and hair loss, and enhance liver and metabolic health.
Adult acne is often a manifestation of metabolic imbalances. Our supplement is specifically designed to address these underlying issues. It combines a powerful blend of ingredients, including Guttuinia extract, Glutathione, Licorice, Turmeric, Kiwi seeds, Selenium, Vitamins E, B1, B6, B12, Job’s Tears extract, and Black Pepper extract.
(Tetrahydrocurcumin with 95% Curcumin content):
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Tetrahydrocurcumin (THC), a powerful derivative of turmeric (curcumin), is a significant metabolite generated when curcumin is reduced by epithelial cells within the intestines. During digestion, a portion of consumed curcumin transforms into THC, known as tetrahydrocurcuminoid (THC), prior to its absorption into the body. This process contributes to its extraordinary purity, standardized to 95%.
Tetrahydrocurcuminoid is a unique variant of curcuminoid that lacks the α, β-unsaturated carbonyl group, resulting in a color spectrum ranging from white to off-white. This distinguishes it from the traditional bright yellow hue typically associated with curcumin.
The conversion of curcumin to THC in the intestine enhances the beneficial properties of curcumin, such as improving liver function and skin health. This effect intensifies as THC levels increase in the body. It’s worth noting that the transformation in the intestine occurs as follows: curcumin first reduces to dihydrocurcumin, and then further reduces to tetrahydrocurcumin (THC)
Antioxidant Effect:
The hydrogenated derivative of curcumin, tetrahydrocurcumin (THC), has been proven to exhibit superior antioxidant activities compared to curcumin itself. In a scientific study published in the Biological and Pharmaceutical Bulletin, it was demonstrated that THC showcases a stronger capacity to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals, as well as more effectively inhibiting 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH) induced linoleic oxidation and red blood cell hemolysis.
This suggests that the hydrogenation process, which transforms curcumin to THC, significantly enhances its antioxidant efficacy. Therefore, THC could potentially be a more potent antioxidant supplement than traditional curcumin.
Liver Protection Effect:
According to a research conducted by Leelavinothan Pari and D. Rosalin Amali, tetrahydrocurcumin (THC), an active component of turmeric, exhibits a stronger protective effect on the liver than curcumin. In their experiment on female Wistar rats, THC, administered at a dose of 80 mg/kg body weight for 8 days prior and 7 days post the single administration of chloroquine, significantly mitigated chloroquine-induced hepatotoxicity. This superior hepatoprotective potency of THC, in comparison to curcumin, signifies its potential in liver health management.
Blood Sugar Control Effect:
Research by Pidaran Murugan and Leelavinothan Pari, which explored the effects of tetrahydrocurcumin (THC) on blood glucose, plasma insulin, and fatty acid composition in streptozotocin (STZ)-nicotinamide induced diabetic rats, revealed potent antidiabetic properties of THC. In this study, THC was administered orally at a dose of 80 mg/kg body weight for 45 days, which resulted in a significant decrease in the concentration of fatty acids like palmitic acid, stearic acid, and oleic acid, while levels of linolenic and arachidonic acid were elevated. The overall effects of THC exhibited were not only antidiabetic, but also antihyperlipidemic, surpassing the effects of curcumin administered at the same dose. This suggests that THC could play a significant role in managing blood sugar levels and lipid profiles in type 2 diabetic patients.
Cholesterol Control Effect:
In the context of hyperlipidemia often associated with diabetes, tetrahydrocurcumin (THC) exerts a beneficial impact on cholesterol control. A study conducted on type 2 diabetic rats, wherein THC was administered at a dosage of 80 mg/kg body weight, revealed the following effects after a 45-day period:
A reversal of the decrease in serum high-density lipoprotein (HDL) cholesterol, signifying an increase in this beneficial cholesterol subtype.
Compared to curcumin given at the same dosage, THC was shown to be more potent in exhibiting these cholesterol control effects. Therefore, THC may serve as an effective agent in managing cholesterol levels, especially in diabetic conditions characterized by hyperlipidemia.
Beauty Effect:
Tetrahydrocurcumin (THC) possesses potent anti-melanogenic properties and helps in maintaining the integrity of collagen, a critical protein for skin health.
Anti-Melanogenic Properties:
In a study conducted using B16F10 melanoma cells, Tetrahydrocurcumin (THC) exhibited remarkable anti-melanogenic properties, significantly inhibiting melanin production and thus potentially combating skin hyperpigmentation. By effectively reducing the expression of essential enzymes involved in melanin biosynthesis – tyrosinase (TYR), tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) – THC demonstrates potential as a powerful agent against skin hyperpigmentation. Furthermore, the research suggested that a lecithin-based nanoemulsion could notably enhance the topical delivery efficiency of THC, paving the way for its effective use in skincare products.
Collagen Maintenance:
A study by Leelavinothan Pari and Pidaran Murugan revealed that tetrahydrocurcumin (THC) can improve collagen health in type 2 diabetes conditions. Diabetes-related glycation can compromise collagen, crucial for skin beauty. However, THC counteracts this, reducing collagen accumulation, cross-linking, and glycation, leading to potential enhancements in skin health. Therefore, THC might be a promising agent for maintaining skin beauty, particularly in diabetes scenarios.
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Glutathione, a tripeptide consisting of glutamic acid, cysteine, and glycine, is an essential constituent of most cells in our body, synthesized predominantly in the liver. It not only regulates metabolic processes and improves liver function but also serves as a key antioxidant defense. Glutathione’s capacity to neutralize harmful oxygen radicals, which could potentially damage cell membranes, and its pivotal role as a principal detoxifier make it a ‘master antioxidant.’
The glutathione in our supplement is derived from the fermentation of Torula yeast, or Candida utilis, historically used as a food additive and protein source since its introduction in Germany during World War I. Today, Torula yeast is globally recognized for its safety and found in a wide variety of food products, thanks to approval by organizations like the FDA in the United States and the EFSA in Europe.
Our supplement features Hithion™ Torula Yeast Extract, which is abundant in amino acids, minerals, nucleotides, and vitamins. This extract is particularly noteworthy for its potential to boost glutathione levels. A decline in these levels, usually due to stress, fatigue, alcohol consumption, smoking, or excessive energy expenditure, can accelerate aging and organ function deterioration. However, regular intake of this extract can help rejuvenate liver functions and improve overall body stamina.
From a skincare perspective, glutathione brings enormous benefits. It effectively counteracts oxidative compounds that threaten to damage cell membranes, DNA, and energy production. Simultaneously, it combats a broad spectrum of modern-day toxins, including pollution, cigarette smoke, and household cleaners. Glutathione is instrumental in detoxification, binding to toxins, escorting them out of cells to the liver for processing, and ultimately ensuring their excretion via kidneys, lungs, or bowels.
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Houttuynia Cordata Extract is a powerful botanical extract renowned for its significant health benefits. This perennial plant, native to East Asia and prevalent in Japan, thrives in moist, shady environments, making it a staple in the local flora.
Research shows that this extract is particularly effective in treating various skin conditions, including acne. It works by aiding in toxin elimination and blood purification, which results in improved skin health. It’s also known to stimulate the metabolic process, leading to enhanced overall bodily function and skin rejuvenation.
Among the active compounds found in Houttuynia Cordata Extract are Quercitrin and Isoquercitrin. These phytochemicals are recognized for their capillary-strengthening effects and their ability to mitigate inflammation in the gastrointestinal tract.
The scientific study “Inhibitory effects of Houttuynia cordata water extracts on anaphylactic reaction and mast cell activation” shed light on the extract’s capacity to inhibit systemic anaphylaxis and mast cell activation, which play a crucial role in allergic conditions such as asthma and allergic rhinitis. It was found that the extract could decrease mast cell degranulation and inhibit histamine release and calcium uptake in these cells, underlining its anti-allergic potential.
Additionally, in the comprehensive review “Therapeutic potentials of Houttuynia cordata Thunb. against inflammation and oxidative stress,” the extract was found to reduce oxidative stress and inflammation effectively. Its key phytochemicals, including afzelin, hyperoside, and quercitrin, were noted for their strong antioxidant and anti-inflammatory actions.
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Ural Licorice, also known as Glycyrrhiza Uralensis, is a medicinal plant, rich in the compound glycyrrhizic acid. This plant has been treasured since ancient times for its profound anti-inflammatory effects and is still a staple in many traditional Chinese medicine prescriptions for conditions such as stomatitis and sore throat.
Glycyrrhizic acid, found in licorice, serves multiple roles in promoting health. Its antioxidant and anti-inflammatory properties contribute to its hepatoprotective action, helping to guard
the liver against damage and inflammation. Additionally, it has been found to inhibit the reproduction of viruses in the liver and other organs, largely due to its ability to stimulate the production of interferons, enhance phagocytosis, and increase the activity of natural killer cells.
Furthermore, glycyrrhizic acid exhibits membranostabilizing activity, helping to maintain the integrity of cell membranes, particularly in the liver. It potentiates the action of endogenous glucocorticoids, leading to pronounced anti-inflammatory and anti-allergic effects, especially in non-infectious liver diseases.
In skincare, glycyrrhizic acid can regulate sebum production and maintain skin balance, reducing the likelihood of skin issues such as acne.
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Kiwi Seed Extract is a concentrated and beneficial substance that has garnered significant attention in research due to its diverse health benefits. Renowned for its unique properties, it’s often incorporated as a critical component in advanced dietary supplements.
The extract, derived from kiwi seeds, is known for its potent effects in several aspects of health and wellness:
Inhibition of Dihydrotestosterone (DHT) Production:
Kiwi Seed Extract has been shown to suppress the production of DHT. DHT is a hormone that can increase the secretion of sebum, an oil produced by the skin that can lead to acne when produced in excess. By inhibiting the production of DHT, Kiwi Seed Extract can help to reduce the incidence and severity of acne.
Lipase Inhibition:
Certain bacteria that live in the hair follicles, such as Propionibacterium acnes, produce an enzyme called lipase. Lipase can lead to inflammation and acne when it breaks down the oil and fats in the skin. Kiwi Seed Extract has been found to inhibit the action of this enzyme, helping to prevent inflammation and acne.
Anti-aging Benefits:
Studies have also suggested that Kiwi Seed Extract can help to protect against wrinkles and dark circles under the eyes. It’s rich in α-Linolenic acid, an essential omega-3 fatty acid, and natural tocotrienols, powerful antioxidants that can help to combat the signs of aging.
Polyphenol Content:
Kiwi seeds are rich in polyphenols, compounds that have strong antioxidant properties. Antioxidants can help to protect the body against damage caused by free radicals, unstable molecules that can lead to cell damage and various health problems.
Flavonol Glycosides:
Kiwi seed extract contains flavonol glycosides, specifically quercitrin and kaempferol 3-O-rhamnoside, which are key components. These compounds offer relief for liver diseases, inhibit advanced glycation end-product (AGE) formation, and inhibit tyrosinase activity (an enzyme involved in skin pigmentation, the inhibition of which can help to manage hyperpigmentation and maintain an even skin tone).
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Coix Seed Extract, also known as Job’s Tears, possesses valuable skin benefits. Proteolytic enzymes within the seeds soften the keratin layers of the skin, leading to smoother texture, reduced wrinkles, and improved dark spots. Additionally, the extract is beneficial in managing various skin issues like acne breakouts, eczema, rosacea, sebum production, warts, and skin allergies such as heat rashes, as well as skin sensitivity.
Regular consumption of Job’s Tears can reduce hyperpigmentation and hydrate the skin. In Japan, a highly concentrated extract of Coix Seeds is recommended for maintaining beautiful skin, hair, and nails.
The extract contains a compound called “Coixenolide,” which aids in treating warts and skin roughness. The seeds of Job’s Tears are also composed of high-quality amino acids, proteins, calcium, potassium, iron, vitamin B group, lipids, and carbohydrates, contributing to overall body metabolism.
A traditional Japanese (Kampo) medicine known as “Yokuinin” is derived from the seeds of Job’s Tears. Historically used for skin benefits, it offers anti-inflammatory properties and assists in balancing the body’s moisture. Effective against skin roughness and warts, Yokuinin activates skin turnover, promotes the metabolism of skin moisture, and facilitates the elimination of waste products. Thus, it improves the circulation of water and nutrients in the skin, helping regulate skin turnover.
Furthermore, a study noted the promising effect of a Kampo medicine, Keishibukuryogan-ka-yokuinin, on squamous papilloma, which is a combination of Keishibukuryogan and Yokuinin. While Keishibukuryogan is believed to benefit skin or oral mucosal remodeling, Yokuinin exhibits potential antiviral properties. The medication was well-tolerated and led to the spontaneous prolapse of the wart without any recurrence.
In summary, Coix Seed Extract offers various skin benefits, ranging from smoothing the skin texture, reducing hyperpigmentation, managing skin conditions, to improving skin’s moisture balance. The presence of unique compounds like Coixenolide and the derivative Yokuinin underlines its potential as a significant contributor to skin health and beauty.
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BioPerine® is a patented, standardized extract derived from Piper nigrum (black pepper) fruits, widely known for its bioavailability-enhancing properties. This natural ingredient considerably enhances the absorption and benefits of nutritive compounds, thus providing a broad spectrum of health benefits.
The active compound in BioPerine® is piperine, a spicy alkaloid, and it’s considerably higher in concentration (95-99%) in BioPerine® than in black pepper, where it’s found in only 3-9% concentrations. The black pepper fruit, grown in Southern India, is the source of this ingredient.
A few theories suggest mechanisms of action for BioPerine®:
BioPerine® is produced in FDA‐inspected, cGMP-compliant facilities in India. Black pepper’s potential as a bioavailability enhancer is utilized in this extraction. Black pepper (Piper nigrum L.) has traditional medicinal uses due to its active pharmaceutical ingredient, a pungent nitrogenous alkaloid. It’s used to treat conditions such as epilepsy, headaches, and diabetes.
Piperine has a low risk of toxicity, is non-genotoxic, and doesn’t produce significant side effects even at supra-physiological doses. Its various medical properties and advantageous safety profiles ease its pharmaceutical usage as a dietary and health supplement. As a result, BioPerine® capsules, a black pepper extract, are commercially available and contain up to 15 parts per million as a food ingredient.
BioPerine® is administered with vitamins, minerals, and some nutritive compounds as a bioavailability enhancer. The thermogenic effect is a manifestation of the biological activity of piperine in black pepper. BioPerine®, a standardized extract of Piper nigrum L. containing 95% piperine, stimulates thermogenic action in the epithelial cells of the small intestine. This acts as a thermogenic element that facilitates enhanced absorption and bioavailability of nutrients.
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Vitamin E within the supplement contains tocopherols and tocotrienols. These elements provide hydration to the skin, support its glow, and improve moisturization. They also promote skin regeneration, replacing dead cells with healthier ones for a radiant complexion.
Selenium, a potent antioxidant, is also included in the supplement. It aids in slowing down the aging process of cells, supports metabolism regulation, and facilitates the absorption of Vitamin E.
The supplement is also fortified with a B Vitamins complex – B1, B2, B6. These vitamins are instrumental in enhancing the growth processes, encouraging tissue regeneration, and improving tissue respiration. They also positively affect the central nervous system’s health and the liver’s detoxification functions.
