ANA GAIN™ Nu Hair & Nail Capsules

Description:

AnaGain™ NU is a plant-based active ingredient derived from organic pea sprouts that promotes hair growth and reduces hair loss. It works by prolonging the anagen phase of the hair growth cycle, which is the active growth phase of hair follicles, by activating key signaling pathways in the hair follicle. This leads to denser and healthier hair growth. AnaGain™ NU is a safe and effective solution for anyone looking to improve the overall health and appearance of their hair.

 

Causes of Hair Loss:

Hair loss, medically referred to as alopecia, is the result of an unbalanced hair growth cycle. This imbalance manifests as a decrease in active (anagen) hair follicles, coupled with a rise in degrading (telogen) follicles. This condition may be attributed to hormonal fluctuations, poor nutrition, environmental influences, and psychological stress. Half of the male population and a quarter of the female population suffer from hair loss by the time they reach 50. Women typically exhibit a more generalized, or diffuse, hair loss, predominantly affecting their scalp’s crown, whereas men may experience a broader hair loss scope, primarily impacting their temples and crown.

AnaGain™ NU serves as a potent enhancer of natural hair growth. It operates by stimulating specific signaling molecules within the dermal papilla cells, critical for initiating the growth of new hair. As such, this product offers a promising solution for those grappling with the universal issue of hair loss.

 

Hair Growth Cycle:

During hair growth, the follicles follow a cyclical and asynchronous growth phase, which is made up of three distinct phases: anagen, catagen, and telogen. Each hair passes through the phases independently of the neighboring hairs. Anagen is the active growth phase, which lasts for two to six years. Catagen is a transitional phase that lasts for two to three weeks, during which the hair follicle shrinks and detaches from the dermal papilla. Telogen is the resting phase, which lasts for three to four months, during which the hair follicle is inactive before it sheds and the cycle starts again.

 

AnaGain™ NU:

AnaGain™ NU was developed using a bioassay-guided approach based on DNA microarray technology. It stimulates specific signaling molecules in the dermal papilla cells, which are required to initiate the growth of new hair. Noggin, a protein that shortens the hair telogen phase, and FGF7, fibroblast growth factor-7, which promotes the proliferation of the matrix keratinocytes at the beginning of a new anagen phase are the two signaling molecules stimulated by AnaGain™ NU.

Furthermore, AnaGain™ Nu contains a high content of L-arginine, an amino acid that supports microcirculation in the dermal papilla cells of the scalp. This further enhances the effectiveness of AnaGain™ Nu in promoting hair growth and reducing hair loss.

 

Bioassay Study Results:

Gene expression analysis was conducted on plucked hair bulbs following a two-week treatment with 2% AnaGain™ NU. The study results showed an up-regulation of Noggin by 56% and FGF-7 by 85%. These results demonstrate that AnaGain™ NU is able to stimulate the dermal papilla to induce the growth of a new hair.

 

Clinical Study Results:

The effects of AnaGain™ NU on hair loss were evaluated on a test panel comprising 21 volunteers suffering from mild to moderate hair loss. 100mg of AnaGain™ NU was taken on a daily basis by the volunteers in a drink of their choice for a period of two months. Hair loss counts were evaluated over three days – at the beginning of the study, following one month and after two months. AnaGain™ NU showed a statistically significant hair loss reduction after one month (-34%) and two months (-37%). Visibly improved hair density was also observed. The volunteers noticed the hair loss reduction and wished to continue the application.

 

Benefits:

AnaGain™ NU is a natural hair growth enhancer that is prepared from edible and organic pea shoots (Pisum sativum). It is developed by a bioassay-guided approach that enhances the expression of FGF7 and Noggin, which balance the hair growth cycle. AnaGain™ NU is clinically proven to be effective for both oral and topical applications in both genders.

 

Conclusion:

AnaGain™ NU is a natural hair growth enhancer that has been developed to stimulate specific signaling molecules in the dermal papilla cells, which are required to initiate the growth of new hair. It is clinically proven to be effective for both oral and topical applications in both genders. It is prepared from edible and organic pea shoots (Pisum sativum) and is developed by a bioassay-guided approach that enhances the expression of FGF7 and Noggin, which balance the hair growth cycle. AnaGain™ NU is a safe and effective solution for individuals who are experiencing hair loss and wish to improve their hair density and growth.

Pea Sprout Extract:

Pea sprout extract is the source of the patented component AnaGain™ NU, which has been shown to be effective in promoting the growth of new hair.

Pea sprout extract, also known as Pisum Sativum sprout extract, is a natural ingredient extracted from the young shoots of the common garden pea. These young shoots are particularly rich in secondary plant metabolites, including isoflavones, which have been shown to have beneficial effects on human health. Secondary metabolites are plant compounds that are not required for the primary metabolic processes like growth and reproduction, but play a crucial role in protecting the plant from various environmental stresses.

The benefits of pea sprout extract in promoting hair growth are numerous. Here are some key advantages of using pea sprout extract:

• Increases the number of anagen hair follicles: Pea sprout extract promotes hair growth by increasing the number of hair follicles in the anagen phase, the active growth phase.
• Reduces the number of telogen hair follicles: Pea sprout extract reduces the number of hair follicles in the telogen phase, the resting phase where hair sheds and falls out.
• Stimulates dermal papilla cells: Pea sprout extract stimulates specific signaling molecules in the dermal papilla cells, which are required to initiate the growth of new hair.
• Balances hair growth cycle: Pea sprout extract enhances the expression of FGF7 and Noggin, which balance the hair growth cycle.
• Restores hair growth life cycle: By reducing the telogen phase of hair follicles, pea sprout extract restores the hair growth life cycle, resulting in the growth of new hair.

 

Keratin:

Keratin is a fibrous protein that makes up nearly 90% of the human hair shaft. However, the amount of keratin in hair can vary depending on hair type, location, and natural hair color.
Keratin also plays an important role in protecting hair from environmental stressors and damage. When there is a lack of keratin in the hair structure, the protective layer of the hair (cuticle) stops retaining moisture, causing the hair to become porous and brittle. As a result, the cuticle scales begin to separate from each other, making the hair appear dull, prone to split ends, and tangled.

Moreover, negative environmental factors, stress, aggressive diets, and poor nutrition can lead to a loss of natural keratin in the hair. Each of these factors can disrupt metabolism in the body and cause a lack of amino acids necessary for keratin production.

The keratin ingredient found in AnaGain™ NU is a high-quality hydrolyzed keratin from chicken feathers with high absorption. Keratin contains glutamic acid, which plays a central role in amino acid metabolism in the body, proline, which is abundant in collagen, and serine, which is a component of the natural moisturizing factor (NMF), among other ingredients.

The natural moisturizing factor (NMF) is a complex of molecules located on the surface of the stratum corneum, the outermost layer of the skin, that have the ability to attract moisture. NMF is composed of amino acids (40-48%) and their metabolites, with the most significant being the salt of glutamic acid – sodium pyrrolidone carboxylic acid (Na-PCA) (10-12%). Skin dryness is characterized by symptoms such as roughness, a feeling of tightness, irritation, and flakiness. In most cases, these symptoms are caused by dehydration of the stratum corneum.

The formation of NMF is closely related to the growth and development of the main cells of the epidermis – keratinocytes. As keratinocytes develop, they accumulate keratin and other proteins that gradually fill their cytoplasm. At the final stages of keratinocyte transformation, they release part of their content, including filaggrin, a special protein. After that, enzymes break down filaggrin into amino acids, which become NMF amino acids.

 

Benefits for Hair and Nails:

• Protecting hair from environmental stressors and damage, by forming a protective layer around the hair shaft that shields it from harmful UV radiation, pollution, and other external factors that can cause hair damage and breakage.

 

• Preventing hair from becoming porous and brittle, by helping to maintain the integrity of the hair shaft and its cuticles, which are responsible for keeping moisture inside the hair. This makes hair less prone to dryness, frizz, and split ends.

 

• Improving hair appearance by making it shiny, smooth, and manageable, by filling in gaps and irregularities in the hair shaft and cuticles, smoothing down the hair surface, and reducing tangling and knotting.

 

• Nourishing hair with amino acids that are essential for hair growth and health, by providing the building blocks that hair follicles need to produce strong and healthy hair. Keratin contains several amino acids, including cysteine, which is particularly important for keratin synthesis.

 

• Supporting the natural moisturizing process of the skin, by helping to maintain the skin’s natural moisture barrier and preventing dehydration. Keratin contains serine, an amino acid that is a key component of the skin’s natural moisturizing factor (NMF), which helps to retain water in the skin and keep it hydrated.

 

• Improved appearance: The use of hydrolyzed keratin as a dietary supplement can improve the appearance of nails by reducing irregularities near the center of the nail and making them look shinier and glossy.

 

• Increased moisture retention: The study showed an increase in the water content of nails after taking hydrolyzed keratin supplements. This can prevent nails from becoming dry and brittle.

 

• Improved nail quality: The use of hydrolyzed keratin supplements can improve the quality of the nail plate by reducing the white portion of the nail plate, thus improving the overall surface of the nail.

 

 

Camellia Seed Extract (Camellia japonica):

Sourced from Toshima Island in Tokyo, Camellia seed extract is a potent ingredient in the hair care supplement AnaGain™ NU, offering a range of scientifically-supported benefits for hair and skin health:

 

• Enhances Blood Circulation: Camellia seed extract is rich in Camellia saponin B2, which promotes nitric oxide production in vascular endothelial cells. This leads to blood vessel dilation, improved blood flow, and better nutrient delivery to the hair follicles, supporting healthier hair growth.

 

• Boosts Skin and Hair Hydration: Clinical trials have shown that Camellia seed extract effectively increases skin moisture levels. Participants aged 20 to 60 experienced an average increase of 14% in facial moisture and 21% in upper arm moisture after eight weeks of consumption. This improved hydration can also benefit hair health, providing essential moisture for strong and shiny hair.

 

• Offers Anti-Glycation Effects: Camellia seed extract has confirmed anti-glycation properties, which help prevent the formation of harmful advanced glycation end-products (AGEs). These substances contribute to aging and skin issues such as wrinkles and dullness. By counteracting glycation, the extract supports a youthful appearance and healthier skin.

 

• Supports Fibroblast Activity and Production of Skin Components: Camellia seed extract can stimulate the activity of skin cells (fibroblasts), supporting the production of vital skin components like collagen and hyaluronic acid. These components play a significant role in maintaining skin elasticity and moisture.

 

 

Fibroblasts:

Fibroblasts are responsible for producing essential skin components such as collagen, elastin, and hyaluronic acid.

Collagen:

Comprising 70% of the dermis, collagen is a fibrous protein that forms a helical structure, providing support to the skin. It is closely related to skin elasticity.

Hyaluronic Acid:

This jelly-like substance connects cells and enhances collagen elasticity. Known for its high water retention capacity, hyaluronic acid is crucial for maintaining skin hydration.
By promoting fibroblast proliferation and the production of collagen and hyaluronic acid, Camellia seed extract helps maintain skin elasticity, firmness, and moisture, leading to healthier, more vibrant skin and hair.

 

BioPerine®:

BioPerine® is a patented extract sourced from black pepper containing a minimum of 95% piperine, and is clinically studied for its ability to enhance nutrient bioavailability. It has been recognized as a bioavailability enhancer for nearly two decades, and is the only source of black pepper to have undergone clinical studies in several countries.

 

Bioavailability and its Role in Nutrient Absorption:
Bioavailability is essential to nutrient absorption and efficacy, but various bioactives face bioavailability as a major drawback for their pharmacological implications. Several delivery methods have been employed to improve absorption, but natural nutrients with the ability to influence bioavailability are being pursued.

 

Mechanisms of Action:
BioPerine® enhances bioavailability through various mechanisms, including inhibition of P-glycoprotein (P-gp), inhibition of enzymes involved in glucuronidation, and enhancing thermogenesis, a metabolic process that generates energy at the cellular level.

 

Benefits:
BioPerine® has been shown to enhance the bioavailability of various nutrients, including fat-soluble and water-soluble vitamins, selenoamino acid, coenzyme Q10, resveratrol, and curcumin. Its ability to improve nutrient absorption can help maximize the benefits of supplements and vitamins.

 

BioPerine® vs. Black Pepper:
While black pepper is the source of BioPerine®, direct intake of black pepper will not achieve enhanced nutrient absorption. BioPerine® must be taken in the right place at the right time in the digestive tract with supplemented nutrients to achieve increased absorption. A purified extract of piperine is necessary for the bioavailability enhancing property to be released, making BioPerine® a more effective option than raw black pepper.

 

Safety:
BioPerine® has received Generally Recognized As Safe (GRAS) status after extensive safety and toxicology data review, and is supported by an independent panel of experts who evaluated its safety for use in a variety of foods.

 

Cystine & L-cysteine:

Cystine is an amino acid that consists of two molecules of L-cysteine linked together by a disulfide bond. This compound is called cystine. Cystine is the oxidized form of cysteine and is more stable in the environment.

L-cysteine is the primary building block for the synthesis of cystine in the body. After the ingestion of food containing L-cysteine, the body breaks the disulfide bond, converting cystine back into L-cysteine. L-cysteine can then be utilized for various processes in the body, including protein synthesis, glutathione formation, and other biologically active compounds.

Cystine and L-cysteine have distinct properties and functions. L-cysteine is the biologically active form that participates in many biological processes, such as protein synthesis, antioxidant protection, and mucolytic action. Cystine, on the other hand, is the oxidized form that possesses more stable properties and serves as a stored and transportable reserve of L-cysteine in the body.

Both cysteine and L-cysteine are important for the body and perform a range of functions, but L-cysteine is the more active form used directly in biological processes. Cystine, as the oxidized form, can serve as a reservoir of L-cysteine, which can be converted back into L-cysteine as needed.

It is important to note that both cysteine and L-cysteine can be obtained from dietary sources (such as meat, poultry, fish, dairy products, legumes, and eggs) as well as from supplemental sources. L-cysteine in the form of N-acetylcysteine (NAC) is the most common form available as a dietary supplement.

 

Gagome Seaweed Extract (Kjellmaniella crassifolia sp.):

Gagome seaweed extract, derived and purified from the Kjellmaniella crassifolia species, is a 100% natural extract found in the AnaGain™ NU supplement. This type of seaweed is abundant in the waters of the eastern coast of Hakodate, on the island of Hokkaido in Japan.

Gagome seaweed is known for its high content of mucous substances, which are rich in valuable components like fucoidan, alginate, laminarin, and other water-soluble viscous polysaccharide compounds.

Gagome seaweed contains amino acids, alginate, fucoidan, which activates natural killer (NK) cells with polysaccharides, as well as carrageenan and laminan mucous membrane.

In particular, Gagome seaweed contains iodine, which helps in the metabolism of lipids and sugars and prevents fat accumulation in the body, making it effective as a dietary supplement and for metabolic syndrome. Iodine is a necessary element for the synthesis of thyroid hormones that regulate critical processes in our bodies. If the diet lacks sufficient iodine, practically all organs suffer. Iodine also has anti-aging effects, helping to maintain the beauty of the skin and hair.

In the AnaGain™ NU supplement, 100mcg of iodine is included, which corresponds to the minimum daily requirement for iodine intake from the daily diet.

 

 

Black Sesame Extract:

Black sesame extract is a natural ingredient derived from black sesame seeds. It is known for promoting improved blood circulation and delaying the appearance of gray hair. The extract is also effective in preventing hair thinning and loss.

 

Mechanism of action:

The extract contains sesamin, which is known for its ability to prevent hypertension and regulate liver function and lipid metabolism. Sesamin has been found to be beneficial for hair health and can help slow down the aging of melanocytes. Black sesame extract is rich in vitamin E, vitamins B1 and B2, protein, and anthocyanins, which are important nutrients for hair health. The extract also contains calcium, magnesium, copper, and zinc, which support the production of melanin and hair growth.

 

Benefits:

Black sesame extract can improve hair health and prevent hair thinning, loss, and premature graying. It also promotes improved blood circulation, which enhances nutrient delivery to the scalp and hair follicles. Additionally, the extract’s antioxidants help protect the body against the damaging effects of free radicals and UV radiation.

 

 

Zinc Yeast:

 

Zinc is a crucial micronutrient that is essential for various biological processes in the body, including immune function, protein synthesis, and wound healing. For skin and hair health, it is considered the primary microelement. Its deficiency can lead to skin issues such as eczema, acne, and hair loss.

AnaGain™ NU, we use zinc in the form of mineral yeast, which is a food material that enhances zinc content in yeast by adding inorganic minerals such as sulfates and carbonates during yeast cultivation. Zinc yeast is a safe and effective source of zinc, as it is almost unaffected by external contamination.

Though natural sources of zinc such as oyster meat extract and seaweed extract exist, they may contain harmful substances such as arsenic, heavy metals, and organic tin. Zinc yeast, on the other hand, is a reliable and safe source of zinc.

Studies show that zinc yeast has a higher absorption rate in the intestine and is more easily absorbed by the intestinal mucous membrane than zinc gluconate. Additionally, the total amount of zinc passing through the circulatory system is approximately twice that of zinc oxide.

Our manufacturer, Medience, has been working with yeast for about 140 years, starting with the brewing industry. The yeast used in AnaGain™ NU supplement was selected for its high resistance to zinc.

Furthermore, we conducted X-ray diffraction measurements at an external analytical institution in Japan, confirming that there is no residual inorganic zinc around the fermenter, making our product safe.

In conclusion, zinc is crucial for maintaining healthy skin and hair, and the use of zinc yeast in AnaGain™ NU ensures a safe and effective source of this essential micronutrient.

 

Vitamins for Healthy Hair:

We have included all the important vitamins that play a vital role in providing the necessary nourishment to hair follicles and ensuring strong, healthy hair.

 

Complex of B Vitamins:

B1, also known as thiamine hydrochloride, plays a key role in regulating metabolic processes, providing hair follicles with the necessary energy to support healthy hair growth.

B2, or riboflavin, supplies oxygen to the cells of the scalp, allowing nutrients to penetrate the hair roots more effectively. It also improves blood circulation and regulates metabolic processes, ensuring that hair receives the proteins, fats, and carbohydrates it needs to thrive.

B6, or pyridoxine hydrochloride, helps prevent itching and dryness of the scalp – two common causes of dandruff.

B12, or cyanocobalamin, is involved in the synthesis of blood cells, which supports hair growth and strengthens the hair roots. It also improves the quality of the blood, providing essential nutrients to the hair roots. B12 can awaken dormant hair follicles, leading to increased hair density.

 

Vitamin E:

Vitamin E or tocopherol, is a powerful antioxidant that helps prevent destructive oxidative processes in the body. Scientists have shown that 34.5% of people experience accelerated hair growth when taking vitamin E for eight months.

 

Calcium Pantothenate:

It also known as vitamin B5, has a metabolic effect that speeds up the regeneration process. It participates in fat and carbohydrate metabolism and is commonly used for hair restoration.

 

Biotin:

Biotin or vitamin B7, is essential for healthy hair growth. A deficiency of biotin can lead to hair loss. Biotin stimulates the production of erythrocytes, which transport oxygen and nutrients to the scalp and hair follicles.

 

Cystine:

Cystine, an essential amino acid and a crucial component of L-cysteine. It offers a range of benefits that support skin’s metabolic balance and overall hair health:

 

• Balancing Skin Metabolism: Cystine, through its L-cysteine component, helps regulate the skin’s metabolic processes, improving common concerns such as pigmentation, roughness, and uneven tone. This results in a clearer and more radiant complexion.

 

• Strengthening Hair: Cystine is a vital building block for keratin, the primary protein found in hair. By providing the necessary amino acids, cystine promotes the growth of strong, healthy hair and helps prevent hair loss, breakage, and damage.

 

• Boosting Energy Production: L-cysteine, derived from cystine, aids in the efficient production of energy required by the body, supporting metabolic processes. This not only benefits overall health but also contributes to healthier hair and skin by ensuring that cells receive the energy needed for proper function and growth.

 

• Providing Antioxidant Protection: L-cysteine offers antioxidant benefits, neutralizing the harmful effects of free radicals produced by stress and exposure to ultraviolet (UV) radiation. This antioxidant action helps protect the skin and hair from damage, maintaining a vibrant appearance and slowing down the signs of aging.

 

In summary, cystine is a valuable ingredient in AnaGain™ NU, contributing to the enhancement of skin’s metabolic equilibrium and overall hair health. By promoting balanced skin metabolism, strengthening hair, boosting energy production, and providing antioxidant protection, cystine supports the overall health and appearance of both skin and hair.